粘蛋白5B(MUC5B)單克隆抗體
Monoclonal Antibody to Mucin 5 Subtype B (MUC5B)
MUC5-B; MUC9; MG1; Oligomeric Mucus/Gel-Forming; Mucin 5,Subtype B,Tracheobronchial; Cervical mucin; High molecular weight salivary mucin MG1; Sublingual gland mucin
- 編號UMAA684Hu21
- 物種Homo sapiens (Human，人) 相同的名稱，不同的物種。
- 來源單抗制備
- 宿主小鼠
- 效價(克隆號)C10
- Ig亞型 IgG2b Kappa
- 純化方式蛋白A + 蛋白G親和純化
- 標記物無標記物
- 免疫原 RPA684Hu02-粘蛋白5B(MUC5B)重組蛋白
- 緩沖液成份0.01M 磷酸鹽緩沖液（pH7.4，containing 0.05% Proclin-300，50% glycerol）
- 性狀液體
- 濃度1mg/ml
- 且適物種-
- 應(yīng)用WB,ICC/IF
如果抗體需用于流式細胞術(shù)，請參見流式抗體。 - 下載 英文說明書 中文說明書
- 規(guī)格 20μl100μl 200μl 1ml 10ml
- 價格 ¥ 312 ¥ 729 ¥ 1041 ¥ 2603 ¥ 10410
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產(chǎn)品包裝(模擬)
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產(chǎn)品包裝(模擬)
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AF488 staining on IF;
Sample: HepG2 cell
Primary Ab: 20μg/ml Mouse Anti-Human MUC5B Antibody
Second Ab: 2μg/ml AF488-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
(Catalog: SAA544Mu11)
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Western Blot; Sample: Human Serum Primary Ab: 2μg/mL Mouse Anti-Human MUC5B Antibody Second Ab: 0.2μg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody (Catalog: SAA544Mu19)
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通過ISO 9001、ISO 13485質(zhì)量體系認證
特異性
該抗體是針對MUC5B的小鼠單克隆抗體。在免疫組織化學(xué)染色和免疫印跡實驗中能識別MUC5B。
用法
Western blotting: 0.5-2μg/mL;
Immunohistochemistry: 5-20μg/mL;
Immunocytochemistry: 5-20μg/mL;
Optimal working dilutions must be determined by end user.
儲存
經(jīng)常使用則4°C保存。-20°C保存不超過兩年。避免反復(fù)凍融。
穩(wěn)定性
熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗決定，具體方法如下：在37°C孵育48小時，沒有顯著的降解或者沉淀產(chǎn)生。保質(zhì)期內(nèi)，在適當?shù)臈l件下存儲，損失率低于5%。
贈品
增值服務(wù)
相關(guān)產(chǎn)品
| 編號 | 適用物種：Homo sapiens (Human，人) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| URPA684Hu02 | 粘蛋白5B(MUC5B)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| URPA684Hu01 | 粘蛋白5B(MUC5B)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UCPA684Hu21 | 粘蛋白5B(MUC5B)卵白蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| UPAA684Hu01 | 粘蛋白5B(MUC5B)多克隆抗體 | WB |
| UPAA684Hu02 | 粘蛋白5B(MUC5B)多克隆抗體 | WB; IHC; ICC; IP. |
| ULAA684Hu81 | 粘蛋白5B(MUC5B)多克隆抗體(異硫氰酸熒光素標記) | WB; IHC; ICC; IF. |
| ULAA684Hu71 | 粘蛋白5B(MUC5B)多克隆抗體(生物素標記) | WB; IHC; ICC. |
| UMAA684Hu27 | 粘蛋白5B(MUC5B)單克隆抗體 | ICC/IF |
| UMAA684Hu28 | 粘蛋白5B(MUC5B)單克隆抗體 | IHC |
| UMAA684Hu21 | 粘蛋白5B(MUC5B)單克隆抗體 | WB,ICC/IF |
| UMAA684Hu22 | 粘蛋白5B(MUC5B)單克隆抗體 | WB |
| UMAA684Hu23 | 粘蛋白5B(MUC5B)單克隆抗體 | IHC |
| UMAA684Hu24 | 粘蛋白5B(MUC5B)單克隆抗體 | IHC |
| UMAA684Hu25 | 粘蛋白5B(MUC5B)單克隆抗體 | IHC |
| UMAA684Hu29 | 粘蛋白5B(MUC5B)單克隆抗體 | WB |
| USEA684Hu | 粘蛋白5B(MUC5B)檢測試劑盒(酶聯(lián)免疫吸附試驗法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| USCA684Hu | 粘蛋白5B(MUC5B)檢測試劑盒(化學(xué)發(fā)光免疫分析法) | Chemiluminescent immunoassay for Antigen Detection. |
| ULMA684Hu | 粘蛋白5B(MUC5B)等多因子檢測試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
參考文獻
| 雜志 | 參考文獻 |
| The Journal of Biological Chemistry | The Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase/Ribosomal S6 Protein Kinase 1 Cascade Phosphorylates cAMP Response Element-binding Protein to Induce MUC5B Gene Expression via D-Prostanoid Receptor Signaling [Jcb: 34199] |
| The Journal of Biological Chemistry | The ERK MAPK/RSK1 cascade phosphorylates CREB to induce MUC5B gene expression via DP1 receptor signaling [Jcb: 247684] |
| Respiratory Researh | Pyocyanin-induced mucin production is associated with redox modification of FOXA2 [PubMed: PMC3765780] |
| Respirology | Secreted mucins and airway bacterial colonization in non-CF bronchiectasis [PubMed: 26172851] |
| American Thoracic Society International Conference Abstracts | Mucin Secretion In Asthmatics With Osmotic Airway Hyperresponsiveness [doi:10.1164] |
| Ann Am Thorac Soc | Airway Mucin 2 Is Decreased in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization [doi:10.1513] |
| Секреторно-экссудативная реакция слизистой носа на воздействие холодного воздуха у больных бронхиальной астмой [10.20538/1682-0363-2017-2-146-158] | |
| Allergy | Th2 cytokines orchestrate the secretion of MUC 5 AC and MUC 5B in IL‐5 positive chronic rhinosinusitis with nasal polyps [Pubmed:29802623] |
| European?Journal of Pharmacology? | Salvianolic acid B improves airway hyperresponsiveness by inhibiting MUC5AC overproduction associated with Erk1/2/P38 signaling [Pubmed:29382534] |
| Japan Society of Immunology & Allergology in Otolaryngology | インフルエンザ菌Phosphorylcholine の表出と中耳ムチンMUC5AC 及びMUC5B 産生への影響 [10.5648:jjiao.36.7] |
| Journal of Investigative?Medicine | The characteristics and clinical significance of mucin levels in bronchoalveolar lavage fluid of patients with interstitial lung disease [Pubmed: 30573494] |
| Mucosal Immunology | ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism [Pubmed: 31278375] |
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