核因子κB受體激活因子配體(RANkL)多克隆抗體
Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL)
CD254; TNFSF11; ODF; OPGL; TRANCE; HRANKL2; SOdf; Tumor Necrosis Factor(ligand)superfamily Member 11; TNF-related activation-induced cytokine
- 編號UPAA855Ga01
- 物種Chicken (Gallus，雞) 相同的名稱，不同的物種。
- 來源多抗制備
- 宿主兔
- 效價-
- Ig類型 IgG
- 純化方式抗原特異性親和純化
- 標(biāo)記物無標(biāo)記物
- 免疫原 -
- 緩沖液成份磷酸鹽緩沖液（pH7.4,含有0.02% NaN3和50%甘油）
- 性狀液體
- 濃度500μg/mL
- 且適物種-
- 應(yīng)用WB; IHC; ICC; IP.
如果抗體需用于流式細胞術(shù)，請參見流式抗體。 - 下載 英文說明書 中文說明書
- 規(guī)格 20μl100μl 200μl 1ml 10ml
- 價格 ¥ 308 ¥ 718 ¥ 1026 ¥ 2565 ¥ 10260
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產(chǎn)品包裝(模擬)
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產(chǎn)品包裝(模擬)
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通過ISO 9001、ISO 13485質(zhì)量體系認證
特異性
該抗體是針對RANkL的兔多克隆抗體。在免疫組織化學(xué)染色和免疫印跡實驗中能識別RANkL。
用法
免疫印跡：0.2-2μg/mL;1:250-2500
免疫組織化學(xué)：5-20μg/mL;1:25-100
免疫細胞化學(xué)：5-20μg/mL;1:25-100
最佳稀釋倍數(shù)最終由用戶決定。
儲存
經(jīng)常使用則4°C保存。-20°C保存不超過兩年。避免反復(fù)凍融。
穩(wěn)定性
熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗決定，具體方法如下：在37°C孵育48小時，沒有顯著的降解或者沉淀產(chǎn)生。保質(zhì)期內(nèi)，在適當(dāng)?shù)臈l件下存儲，損失率低于5%。
贈品
增值服務(wù)
相關(guān)產(chǎn)品
| 編號 | 適用物種：Chicken (Gallus，雞) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| URPA855Ga01 | 核因子κB受體激活因子配體(RANkL)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UPAA855Ga01 | 核因子κB受體激活因子配體(RANkL)多克隆抗體 | WB; IHC; ICC; IP. |
參考文獻
| 雜志 | 參考文獻 |
| Archives of Oral Biology | Compressive stress induced the up-regulation of M-CSF, RANKL, TNF-α expression and the down-regulation of OPG expression in PDL cells via the integrin-FAK pathway [ScienceDirect: S0003996912003998] |
| PLOS One | Adipokines in Psoriatic Arthritis Patients: The Correlations with Osteoclast Precursors and Bone Erosions [PubMed: PMC3483160] |
| Arthritis Research&Therapy | Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes [PubMed: PMC3672788] |
| International Journal of Oral and Maxillofacial Surgery | The effects of chronic zoledronate usage on the jaw and long bones evaluated using RANKL and osteoprotegerin levels in an animal model [Pubmed: 23522850] |
| AGE | Estrogen deficiency does not decrease the in vitro osteogenic potential of rat adipose-derived mesenchymal stem cells [Pubmed: 24687841] |
| Food Science & Nutrition | Effects and mechanisms of 8-prenylnaringenin on osteoblast MC3T3-E1 and osteoclast-like cells RAW264.7 [Onlinelibrary: fsn3.109] |
| Food Sci Nutr. | Effects and mechanisms of 8‐prenylnaringenin on osteoblast MC3T3‐E1 and osteoclast‐like cells RAW264. 7 [Pubmed:Pmc4221832] |
| Journal of Investigative Surgery | Effect of Nicotine on RANKL and OPG and Bone Mineral Density [Pubmed:24830656] |
| Int J Mol Med. | Effects of icariin on the regulation of the OPG?RANKL?RANK system are mediated through the MAPK pathways in IL?1β?stimulated human SW1353 chondrosarcoma … [Pubmed:25270538] |
| Clinical and Experimental Pharmacology and Physiology | Carvedilol promotes neurological function, reduces bone loss and attenuates cell damage after acute spinal cord injury in rats [Pubmed:25424914] |
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| Sci Rep.? | Sprint Interval Training Induces A Sexual Dimorphism but does not Improve Peak Bone Mass in Young and Healthy Mice. [pubmed:28303909] |
| Sci Rep. | Skeletal Site-specific Effects of Zoledronate on in vivo Bone Remodeling and in vitro BMSCs Osteogenic Activity. [pubmed:28139685] |
| Biomedicine & Pharmacotherapy | Anti-osteoporotic effects of an antidepressant tianeptine on ovariectomized rats [S0753332216322752] |
| BMJ Journals | SAT0003?The Role of 12/15-Lipoxygenase in The Pathogenesis of Osteoporosis in Mice [content:75] |
| Japanese Society for Bone and Mineral Research | Allogeneic yet?major histocompatibility complex?matched bone marrow transplantation in?mice results in?an?impairment of?osteoblasts and?a?significantly reduced trabecular bone [article:10.1007] |
| ONCOLOGY LETTERS | Assessment of bone metabolism and biomechanical properties of the femur, following treatment with anastrozole and letrozole in an experimental model of menopause [ol.2017.6596] |
| Journal of?Clinical?Periodontology? | Peroxisome proliferator‐activated receptor γ plays dual roles on experimental periodontitis in rats [Pubmed:29574908] |
| Journal of Functional Foods | Effect of long-term administration of mangiferin from on bone metabolism in ovariectomized rats [10.1016:j.jff.2018.04.048] |
| International Immunopharmacology | Switched memory B cells promote alveolar bone damage during periodontitis: An adoptive transfer experiment [Pubmed:30015235] |
| European?Journal of Pharmacology | The effect of levetiracetam on rat bone mineral density, bone structure and biochemical markers of bone metabolism [Pubmed:29428468] |
| Journal of?Bone?and?Mineral?Metabolism | Allogeneic yet major histocompatibility complex-matched bone marrow transplantation in mice results in an impairment of osteoblasts and a significantly reduced?… [Pubmed:28766138] |
| Experimental and Therapeutic Medicine | Liraglutide exerts a bone?protective effect in ovariectomized rats with streptozotocin?induced diabetes by inhibiting osteoclastogenesis [Pubmed:29805533] |
| Bone | The sole and combined effect of simvastatin and platelet rich fibrin as a filling material in induced bone defect in tibia of albino rats [Pubmed: 30208342] |
| Journal of?Periodontal?Research | Improved RANKL expression and osteoclastogenesis induction of CD27+ CD38? memory B cells: A link between B cells and alveolar bone damage in periodontitis [Pubmed: 30346027] |
| Bone?Research | NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts [Pubmed: 30455992] |
| Journal of International Dental and Medical Research | Alendronate Effect in RANKL Concentration at Ovariectomized Sprague Dawley Rat. [] |
| Bone | Development and characterization of supramolecular calcitonin assembly and assessment of its interactions with the bone remodelling process [Pubmed: 30797058] |
| Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology | Evaluation of therapeutic effects of teriparatide in a rat model of zoledronic acid-induced bisphosphonate-related osteonecrosis [] |
| Rheumatology International | Comparison of RANKL expression, inflammatory markers, and cardiovascular risk in patients with acute coronary syndrome with and without rheumatoid arthritis [Pubmed: 31297563] |
| World Journal of Pediatrics | Regulation of JAK/STAT signal pathway by miR-21 in the pathogenesis of juvenile idiopathic arthritis [Pubmed: 31641939] |
| Bone | Mice lacking plastin-3 display a specific defect of cortical bone acquisition [Pubmed: 31678489] |
| BIOSCIENCE REPORTS | IL-38 restrains inflammatory response of collagen-induced arthritis in rats via SIRT1/HIF-1α signaling pathway [Pubmed: 32347300] |
| Journal of Ethnopharmacology | Anti-osteoporosis effect of Semen Cuscutae in ovariectomized mice through inhibition of bone resorption by osteoclasts [34801609] |
| Br J Haematol | Inducible T‐cell co‐stimulator (ICOS) and ICOS ligand are novel players in the multiple‐myeloma microenvironment [Pubmed:34954822] |
| Biomed Pharmacother | Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg/Th17 axis [Pubmed:35453007] |
| Phytomedicine | Transcriptomic profiling revealed the role of apigenin-4′-O-α-L-rhamnoside in inhibiting the activation of rheumatoid arthritis fibroblast-like synoviocytes via MAPK?… [Pubmed:35660352] |
| Med Science | Identification of marker proteins in preterm and term birth: Relationship of rankl and HSP70 in the cord blood [] |
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